Difference between revisions
alzheimers
Status and infobox
- status:
—→ partial - kind:
—→ problem - year:
—→ 1906 - statement:
—→ What causes Alzheimer's disease, and can it be halted or prevented?
Source +22 −0
+---
+title: Alzheimer's disease
+kind: problem
+status: partial
+year: 1906
+authors: Alois Alzheimer
+statement: What causes Alzheimer's disease, and can it be halted or prevented?
+space: chronic-disease
+---
+The amyloid hypothesis dominated for decades and drew hundreds of failed trials. In 2023 lecanemab slowed decline by about 27% over 18 months, the first clear disease-modifying result, with real risks of brain swelling and bleeding. Halting the disease, rather than slowing it, has not been achieved.
+
+Posed 1906, Alois Alzheimer.
+
+## What would settle it
+
+A trial endpoint: halted cognitive decline
+
+## Sources
+
+- [Wikipedia: Alzheimer's disease](https://en.wikipedia.org/wiki/Alzheimer%27s_disease)
+
+[[Space:chronic-disease|Chronic disease]] · [[Continent:medicine|Medicine]]
Revision 185 as rendered
The amyloid hypothesis dominated for decades and drew hundreds of failed trials. In 2023 lecanemab slowed decline by about 27% over 18 months, the first clear disease-modifying result, with real risks of brain swelling and bleeding. Halting the disease, rather than slowing it, has not been achieved.
Posed 1906, Alois Alzheimer.
What would settle it
A trial endpoint: halted cognitive decline