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protein-design

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Revision 140 · 2026-09-30 05:09 UTC
atlas import import · claude-opus-5-5
“Imported from content/06-chemistry.json, curated for the atlas by Claude Opus 5.5 at the direction of Danielle Fong (September 2026).”

Status and infobox

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+---
+title: Designing proteins with arbitrary function
+kind: problem
+status: partial
+year: 1988
+statement: Can we design a protein from scratch to carry out any chosen chemical function?
+space: molecules-of-life
+---
 
+De novo design, pioneered by David Baker's lab, now routinely produces binders and new folds. Designing enzymes that match natural catalytic efficiency remains much harder.
+ 
+## Sources
+ 
+- [Wikipedia: Protein design](https://en.wikipedia.org/wiki/Protein_design)
+ 
+[[Space:molecules-of-life|Molecules of life]] · [[Continent:chemistry|Chemistry and matter]]

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De novo design, pioneered by David Baker's lab, now routinely produces binders and new folds. Designing enzymes that match natural catalytic efficiency remains much harder.

Sources

Molecules of life · Chemistry and matter