Difference between revisions
protein-structure-prediction
Status and infobox
- status:
—→ solved - tier:
—→ V3 - kind:
—→ problem - year:
—→ 1972 - statement:
—→ Can a protein's three-dimensional structure be predicted from its amino-acid sequence?
Relations
- + related to protein-design: The original curation links this problem to Designing proteins with arbitrary function; the argument for the link has not been written yet.
Source +30 −0
+---
+title: Protein structure prediction
+kind: problem
+status: solved
+tier: V3
+year: 1972
+authors: Christian Anfinsen: sequence determines structure
+statement: Can a protein's three-dimensional structure be predicted from its amino-acid sequence?
+space: molecules-of-life
+---
+For fifty years this was a grand challenge. CASP, a blind biennial benchmark, served as the verifier: predictors submit structures before experiments are released. AlphaFold 2 reached accuracy comparable to experiment on most targets, and Hassabis, Jumper and Baker shared the 2024 Nobel Prize in Chemistry. Dynamics, disordered proteins and complexes are still open.
+
+*Evidence tier V3 is the import default for a result the curation records as settled in the published record. No formal proof or certificate is attached to this page yet.*
+
+Posed 1972, Christian Anfinsen: sequence determines structure. Closed 2020, AlphaFold 2 at CASP14.
+
+## What would settle it
+
+CASP blind assessment
+
+## Related problems
+
+- The original curation links this problem to [[related::Problem:protein-design|Designing proteins with arbitrary function]]; the argument for the link has not been written yet.
+
+## Sources
+
+- [Wikipedia: AlphaFold](https://en.wikipedia.org/wiki/AlphaFold)
+- [Wikipedia: CASP](https://en.wikipedia.org/wiki/CASP)
+
+[[Space:molecules-of-life|Molecules of life]] · [[Continent:chemistry|Chemistry and matter]]
Revision 139 as rendered
For fifty years this was a grand challenge. CASP, a blind biennial benchmark, served as the verifier: predictors submit structures before experiments are released. AlphaFold 2 reached accuracy comparable to experiment on most targets, and Hassabis, Jumper and Baker shared the 2024 Nobel Prize in Chemistry. Dynamics, disordered proteins and complexes are still open.
Evidence tier V3 is the import default for a result the curation records as settled in the published record. No formal proof or certificate is attached to this page yet.
Posed 1972, Christian Anfinsen: sequence determines structure. Closed 2020, AlphaFold 2 at CASP14.
What would settle it
CASP blind assessment
Related problems
- The original curation links this problem to Designing proteins with arbitrary function; the argument for the link has not been written yet.